Takatsugu Ishimoto
M.D., Ph.D.


      SELECTED PUBLICATIONS(Original articles)

  1. Yasuda T, Koiwa M, Yonemura A, Akiyama T, Baba H, Ishimoto T (As corresponding author). Protocol to establish cancer-associated fibroblasts from surgically resected tissues and generate senescent fibroblasts. STAR Protocols. 2021 in press.
  2.  Yasuda T, Koiwa M, Yonemura A, Miyake K, Kariya R, Kubota S, Yokomizo-Nakano T, Yasuda-Yoshihara N, Uchihara T, Itoyama R, Bu L, Fu L, Arima K, Izumi D, Iwagami S, Eto K, Iwatsuki M, Baba Y, Yoshida N, Ohguchi H, Okada S, Matsusaki K, Sashida G, Takahashi A, Tan P, Baba H, Ishimoto T (As corresponding author). Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination. Cell Rep. 2021 Feb 23;34(8):108779.
  3. Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani J, Tan P, Baba H, Ishimoto T (As corresponding author). Annexin A6 in Extracellular Vesicles from Cancer-Associated Fibroblasts Induces FAK-YAP Activation by Stabilizing β1 Integrin and Enhances Drug Resistance. Cancer Res, 2020 Aug 15;80(16):3222-3235.
  4. Arima K, Ohmuraya M, Miyake K, Koiwa M, Uchihara T, Izumi D, Gao F, Yonemura A, Bu L, Okabe H, Imai K, Hashimoto D, Baba Y, Chikamoto A, Yamashita YI, Furukawa T, Araki K, Baba H, Ishimoto T (As corresponding author). Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas. Oncogene 2019 Feb;38(8):1211-1224.
  5. Eto T, Miyake K, Nosho K, Ohmuraya M, Imamura Y, Arima K, Kanno S, Fu L, Kiyozumi Y, Izumi D, Sugihara H, Hiyoshi Y, Miyamoto Y, Sawayama H, Iwatsuki M, Baba Y, Yoshida N, Furukawa T, Araki K, Baba H, Ishimoto T (As corresponding author). Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression. J Pathol. 2018 Aug;245(4):445-455.
  6. Arima K, Komohara Y, Bu L, Tsukamoto M, Itoyama R, Miyake K, Uchihara T, Ogata Y, Nakagawa S, Okabe H, Imai K, Hashimoto D, Chikamoto A, Yamashita YI, Baba H, Ishimoto T (As corresponding author). Down-regulation of 15-PGDH by interleukin-1 beta from activated macrophages leads to poor prognosis in pancreatic cancer. Cancer Sci. 2018 Feb;109(2):462-470.
  7. Izumi D, Ishimoto T (As corresponding author), Miyake K, Eto T, Arima K, Kiyozumi Y, Uchihara T, Kurashige J, Iwatsuki M, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Goel A, Tan P, Baba H. Colorectal cancer stem cells acquire chemoresistance through the upregulation of FBXW7 and the consequent degradation of c-Myc. Stem Cells 2017 Sep;35(9):2027-2036.
  8. Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang KK, Joyce LN, Kalpana R, Tay ST, Suzuki Y, Cho BC, Kuroda D, Arima K, Izumi D, Iwatsuki M, Baba Y, Oki E, Watanabe M, Saya H, Hirakawa K, Baba H, Tan P. Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells. Gastroenterology. 2017 Jul;153(1):191-204.
  9. Ishimoto T, Izumi D, Watanabe M, Yoshida N, Hidaka K, Miyake K, Sugihara H, Sawayama H, Imamura Y, Iwatsuki M, Iwagami S, Baba Y, Horlad H, Komohara Y, Takeya M and Baba H. * Chronic inflammation with Helicobacter pylori-infection is implicated in CD44 overexpression through miR-328 suppression in the gastric mucosa. J Gastroenterol. 2015 Jul; 50 (7):751-7.
  10. Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Okabe H, Hidaka K, Yokoyama N, Miyake K, Yoshikawa M, Nagano O, Komohara Y, Takeya M, Saya H and Baba H. * Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation. Carcinogenesis 2014 May;35(5):1003-11.
  11. Sawayama H, Ishimoto T (As co-first author), Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H. * Small molecule agonists of PPAR-γ exert therapeutic effects in esophageal cancer. Cancer Res. 2014 Jan 15; 74(2):575-85.
  12. Mima K, Okabe H, Ishimoto T, Hayashi H, Nakagawa S, Kuroki H, Watanabe M, Beppu T, Tamada M, Nagano O, Saya H, Baba H*. CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma. Cancer Res. 2012 Jul 1;72 (13):3414-23.
  13. Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T, Mogushi K, Tanaka H, Osawa T, Kanki Y, Minami T, Aburatani H, Ohmura M, Kubo A, Suematsu M, Takahashi K, Saya H and Nagano O*. Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nat. Commun. 2012 Jun 6;3:883.
  14. Ishimoto T, Nagano O*, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H: CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc- and Thereby Promotes Tumor Growth. Cancer Cell 2011 Mar 8;19(3):387-400.
  15. Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H, Nagano O*. CD44+ slow-cycling tumor cell expansion is triggered by the cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis Cancer Sci. 2010 March; 101(3): 673-678.

      SELECTED PUBLICATIONS(Review articles)

  1. Bu L, Baba H, Yasuda T, Uchihara T, Ishimoto T (As corresponding author). Functional diversity of cancer-associated fibroblasts in modulating drug resistance. Cancer Sci. 2020 Oct;111(10):3468-3477.
  2. Bu L, Baba H, Yoshida N, Miyake K, Yasuda T, Uchihara T, Tan P, Ishimoto T (As corresponding author). Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment. Oncogene. 2019 Jun;38(25):4887-4901.
  3. Ishimoto T*, Baba H, Izumi D, Sugihara H, Kurashige J, Iwatsuki M, Tan P. Current perspectives towards the identification of key players in gastric cancer microRNA dysregulation. Int J Cancer. 2016 Mar 15;138(6):1337-49.
  4. Ishimoto T, Sawayama H, Sugihara H, Baba H*. Interaction between gastric cancer stem cells and the tumor microenvironment. J Gastroenterol. 2014 Jul;49 (7):1111-20.