Our laboratory is working to determine how genetic and epigenetic alterations collaborate to promote the transformation of myeloid malignancies by utilizing comprehensive approaches (e.g. genetically modified mice, CRISPR/Cas9 genome editing, and sequencing analysis such as ChIP-seq, ATAC-seq, and Bisulfate-seq).  Several areas of current investigation in the lab include:

1. Understanding the functions of mutations in transcription factors and epigenetic modifiers in MDS and AML
2. Understanding the molecular mechanism of how environmental stress promotes the development of MDS
3. Understanding the functional role of numerical chromosomal anomalies in the development of MDS

Link to a complete list of Goro Sashida's publications.