Research Articles

1. Takahashi Y, Morales Valencia M, Yu Y, Ouchi Y, Takahashi K, Shokhirev MN, Lande K, Williams AE, Fresia C, Kurita M, Hishida T, Shojima K, Hatanaka F, Nuñez-Delicado E, Rodriquez Esteban C, Izpisua Belmonte JC. Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice. Cell. 2023; 186: 4, 715-731
2. Mutukula N*, Man Z*, Takahashi Y*, Iniesta Martinez F*, Morales M, Carreon-Guarnizo Ester, Hernandez Clares R, Garcial-Bernal D, Martinez Martinez L, Lajara J, Nuñez-Delicado E, Meca Lallana JE, Izpisua Belmonte JC. Generation of RRMS and PPMS specific iPSCs as a platform for modeling Multiple Sclerosis. Stem Cell Res. 2021 Apr 15, *: Contributed equally
3. Li R, Zhong C, Yu Y, Liu H, Sakurai M, Yu L, Min Z, Shi L, Wei Y, Takahashi Y, Liao HK, Qiao J, Deng H, Nunez-Delicado E, Rodriguez Esteban C, Wu J, Izpisua Belmonte JC. Generation of blastocyst-like structures from mouse embryonic and adult cell cultures. Cell. 2019; 179: 3, P687-702
4. Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Sancho-Martinez I, Takahashi Y, Hatanaka F, Wu J, Ocampo A, Reddy P, Wu MZ, Gerken L, Shaw RJ, Rodriguez Esteban C, Benner C, Nakagawa H, Guillen Garcia P, Nuñez Delicado E, Castells A, Campistol JM, Liu GH, Izpisua Belmonte JC. Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway. Protein Cell. 2019 Apr 30/ d132238-019-0630-3
5. Kurita M, Araoka T, Hishida T, O'Keefe DD, Takahashi Y, Sakamoto A, Sakurai M, Suzuki K, Wu J, Yamamoto M, Hernandez-Benitez R, Ocampo A, Reddy P, Shokhirev MN, Magistretti P, Núñez Delicado E, Eto H, Harii K, Izpisua Belmonte JC. In vivo reprogramming of wound-resident cells generates skin epithelial tissue. Nature. 2018; 561:243-247
6. Takahashi Y, Wu J, Suzuki K, Martinez-Redondo P, Li M, Liao HK, Wu MZ, Hernández-Benítez R, Hishida T, Shokhirev MN, Esteban CR, Sancho-Martinez I, Izpisua Belmonte JC. Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. Science. 2017; 356: 503-508.
7. Sha L, Daitoku H, Araoi S, Kaneko Y, Takahashi Y, Kako K, Fukamizu A. Asymmetric Arginine Dimethylation Modulates Mitochondrial Energy Metabolism and Homeostasis in Caenorhabditis elegans. Mol Cell Biol. 2017; 37: e00504-16
8. Daitoku H, Kaneko Y, Yoshimochi K, Matsumoto K, Araoi S, Sakamaki JI, Takahashi Y, Fukamizu A. Non-transcriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis. Mol Cell Biol. 2016; 36: 2755-66
9. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. An alternative pluripotent state confers interspecies chimeric competency. Nature. 2015; 21: 316-21.
10. Liao HK, Gu Y, Diaz A, Marlett J, Takahashi Y, Li M, Suzuki K, Xu R, Hishida T, Chang CJ, Esteban CR, Young J, Izpisua Belmonte JC. Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells. Nat Commun. 2015; 6: 6413.
11. Tamiya H, Hirota K, Takahashi Y, Daitoku H, Kaneko Y, Sakuta G, Iizuka K, Watanabe S, Ishii N, Fukamizu A. Conserved SAMS function in regulating egg-laying in C. elegans. J Recept Signal Transduct Res. 2013; 33: 56-62.
12. Takahashi Y, Daitoku H, Hirota K, Tamiya H, Yokoyama A, Kako K, Nagashima Y, Nakamura A, Shimada T, Watanabe S, Yamagata K, Yasuda K, Ishii N, and Fukamizu A. Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. Cell Metab. 2011; 13: 505-16.
13. Takahashi Y, Daitoku H, Yokoyama A, Nakayama K, Kim JD, and Fukamizu A. The C. elegans PRMT-3 possesses a type III protein arginine methyltransferase activity. J. Recept. Signal Transduct. 2011; 31: 168-72.
14. Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, and Fukamizu A. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol. Cell 2008; 32: 221-31.

Revew and Book chapter

1.  Takahashi Y  Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. Japanese Scientists in Science 2017 2018
2. Takahashi Y Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. Clinical immunology &  allergology 2018
3. Takahashi Y and Izpisua Belmonte JC  Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. Experimental medicine 2017 Sep: 2385-88
4. Takahashi Y and Fukamizu A. Transcription System Linked to Metabolites and Methyl-Group Cycle. Cell Technology2014 Jul: 734-38
5. Takahashi Y and Fukamizu A. Physiological role of arginine methylation. Annual Review diabetes, metabolism, and Endocrinology2012 Jan: 170-75
6. Takahashi Y, Daitoku H, and Fukamizu A.  Physiological role of arginine methylation as an epigenome-mark. Experimental medicine 2011 Sep: 2236-40