September 11 2020
Authors: Ayako Nakamura-Ishizu,Shah Adil Ishtiyaq Ahmad,Toshio Suda
Title: Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails
Trends in Cell Biology
The transplantation of healthy hematopoietic stem cells (HSCs) contained in the bone marrow is a frontline treatment option for hematopoietic diseases. Detailed analysis of post-transplant HSC kinetics is crucial as the initial engraftment of HSCs influences prognosis. Dong et al. have explored the dynamic change in HSC cell fate upon bone marrow transplantation through the utilization of single-cell transcriptomic analysis.
hematopoietic stem; bone marrow transplantation; progenitors; clonal dynamics