IRCMS International Research Center for Medical Sciences

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IRCMS Seminars

[Jan.12] 71st IRCMS seminar

January 4 2021

We would like to inform you that the 71st IRCMS seminar has been scheduled as below.
We would be pleased to see many of you participating in the seminar.

Date       : January 12, 2021 (Tuesday)

Time     : 16:00-17:00
               * To prevent the spread of COVID-19, the seats will be limited to 15.
               * This seminar will be simultaneously distributed by Zoom.

Speaker : Masanori Nakayama, PhD
                Group Leader,
                Max-Planck-Institute for Heart and Lung Research

Tilte       : Transplantation of the hiPSC-derived cardiomyocyte patch alters extra cellular matrix composition directly affecting cardiac fibroblasts after MI

Abstract:

Myocardial infarction (MI) followed by chronic heart failure is the main cause of mortality of heart diseases. To improve heart function after MI, reparative cell transplantation therapies, including stem cell or stem cell-derived cardiomyocyte transplantation, are developed. While the therapeutic effect of transplantation of the stem cells, such as bone marrow mononuclear cells and cardiac progenitor cells, are shown to be presumably due to consequence of an acute sterile immune response, the mode of action of the stem cell-derived cardiomyocyte transplantation therapy remains elusive.

Here, we transplanted hiPSC-derived cardiomyocyte (CM) patch onto the immunodeficient rat after MI. Then, functional recovery of the CM-patch transplanted heart compared to control animal was examined. Under the condition, transcriptome analysis of human derived cells and rat host cells was examined. We found that hiPSC-derived CMs induced collagen type I but not collagen type III production by cardiac fibroblast, resulting in improved alignment of the collagen fibers at the infarcted zone. Furthermore, elasticity of the heart was enhanced in the hiPSC-derived CMs patch transplanted heart compared to control. Consistently, fibrosis in the remote zone was also improved. Our results suggest the direct effect of the transplanted CM patch on the cardiac fibroblasts to improve elasticity of the damaged heart via modulating collagen type I production in the cardiac fibroblasts, resulting in functional recovery after MI.

Reference:
  1. Kawamura A, Kawamura T, Riddell M, et al. Regulation of programmed cell death ligand 1 expression by atypical protein kinase C lambda/iota in cutaneous angiosarcoma. Cancer Sci. 2019;110:1780-1789.
  2. Riddell, M., Nakayama, A., Hikita, T. et al. aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability. Nat Commun 9, 5357 (2018).

Anyone in Kumamoto University who wants to join is welcome; however, please pre-register by the following URL to secure your seat or receive the Zoom meeting information.
http://ircms.kumamoto-u.ac.jp/symposium_reserve/symposium/reservation/



Flyer: (Click for a larger image)

Flyer_71st IRCMS Seminar.jpg