August 20 2020
We would like to inform you that the 68th IRCMS seminar has been scheduled as below.
We would be pleased to see many of you participating in the seminar.
Date : September 2, 2020 (Wednesday)
Time : 17:00-18:00
Venue : IRCMS 1F Meeting Lounge
* To prevent the spread of COVID-19, the seats will be limited to 15.
Please wear a face mask when you join.
* This seminar will be simultaneously distributed by Zoom.
Speaker : Masahiro Ono, MD, PhD
Imperial College London
(Visiting Associate Professor, IRCMS)
Tilte : Mechanisms of T cell-mediated immune regulation at the single cell level
We study temporally dynamic mechanisms underlying T cell differentiation and responses. This seminar will aim to show that, in order to understand immune regulation, it is indispensable to analyse time-dependent dynamics of the differentiation and function of individual T cells. I will discuss recent findings by single cell RNA-seq analysis, which shows that the differentiation of Treg and effector T cells is dynamically regulated in cancer microenvironments (1) and in COVID-19 patients (2). In addition, I will introduce our single-cell tool for time domain analysis, Timer of Cellular Kinetics and Activity(Tocky), and show new temporally dynamic mechanisms of T cell regulation in vivo, which was revealed by the Tocky technology (3, 4). Lastly, future perspectives will be discussed.
Anyone in Kumamoto University who wants to join is welcome; however, please pre-register by the following URL to secure your seat / receive the Zoom meeting information.
(The seats will be secured to participants in order of registration.)