November 15 2017
We had the 31st IRCMS Seminar as followings. We had a large number of participants , for which we would like to express our gratitude.
Date: November 15, 2017 (Wed) Time: 11:00 - 12:00
Venue: 1F Meeting Lounge, IRCMS
Speaker: Kasem Kulkeaw Ph.D.
Assistant Professor, Department of Research and Development of Next Generation Medicine, Faculty of Medical Sciences, Kyushu University, Japan
"Study of a new player in epigenetic regulation of erythropoiesis"
Production of red blood cells or erythrocytes, a process known as erythropoiesis, is tightly regulated in order to produce sufficient number of functional erythrocytes. Epigenetic is one of mechanisms regulating erythropoiesis. In this seminar, I will discuss our current research on epigenetic of erythropoiesis. We identify a new member of GCN5-related N-acetyltransferase family, which we terms GNAT-like protein. GNAT-like protein binds acetyl-coenzyme A, a key source of acetyl group for histone acetylation but lacks histone acetylation activity. By contrast, GNAT-like protein suppresses histone acetylation activity of other histone acetyltransferase in vitro. Gain- and loss-of-function studies show that GNA-like protein likely play three distinct roles in epigenetic; (1) a carrier of acetyl-coenzyme A, (2) a histone acetyltransferase or (3) negative regulator of histone acetylation.
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