March 10:The 11th IRCMS Seminar "Shaping up a lineage: Lessons from B-lymphocyte development"

April 1 2016

We will have the 11th IRCMS Seminar as followings. We hope many of you will join this seminar.

[Date and Time]

March 10, 2016. Thursday 17:00-18:00

[Venue]

1F Conference Room, Institute of Molecular Embryology and Genetics (IMEG)

[Speaker]

Professor Mikael Sigvardsson, Ph.D.

Medical Molecular Biology, Linkoping University, Sweden

Molecular Hematology, Lund University, Sweden

[Abstract]

　The development of mature blood cells from multipotent stem cell is a complex process involving the coordinated activity of transcription factor networks and extracellular signals. We have explored the molecular regulation of B-lymphocyte development using transgenic mouse models. This has revealed that the process involve distinct phases, specification resulting in the activation of the B-lineage program and commitment to abolish alternative cell fates. Even though these processes are linked via auto-regulatory loops they can be functionally separated. The differentiation pathway is linked to malignant transformation thought the action of the transcription factors EBF1 and PAX5, acting in a dose dependent manner to prevent malignant transformation. The seminar will focus on our recent findings revealing that disruption of transcription factor networks in B-cell leukemia allow for plasticity mediating a cross linage transfer of the leukemic state to generate T-lineage disease. Further, the seminar presents a protein association analysis revealing novel regulatory networks involving the targeting of broadly expressed DNA binding proteins to lineage restricted target genes by lineage specifying transcription factors.