IRCMS International Research Center for Medical Sciences

Research

Aiko Sada
Ph.D.
Associate Professor

ACHIEVEMENT

Publications

  1. Raja E, Changarathil G, Oinam L, Tsunezumi J, Ngo YX, Ishii R, Sasaki T, Imanaka-Yoshida K, Yanagisawa H*, Sada A*: The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging. EMBO Rep. e55478, 2022. *Corresponding authors. 
  2. Ngo YX, Haga K, Suzuki A, Kato H, Yanagisawa H, Izumi K*, Sada A*: Isolation and culture of primary oral keratinocytes from the adult mouse palate. J Vis Exp, (175): e62820, 2021. *Corresponding authors. 
  3. Kimura K, Ramirez K, Nguyen TAV, Yamashiro Y, Sada A, Yanagisawa H: Contribution of PDGFRα-positive cells in maintenance and injury responses in mouse large vessels. Sci Rep, 11(1):8683, 2021.
  4. Ichijo R, Kabata M, Kidoya H, Muramatsu F, Ishibashi R, Abe K, Tsutsui K, Kubo H, Iizuka Y, Kitano S, Miyachi H, Kubota Y, Fujiwara H, Sada A, Yamamoto T, Toyoshima F: Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs. Science Advances, 7(7): eabd2575, 2021.
  5. Ishii R, Yanagisawa H*, Sada A*: Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium. Development, 147(24):dev197590, 2020. *corresponding authors. 
  6. Oinam L, Changarathil G, Raja E, Yen Ngo YX, Tateno H*, Sada A*, Yanagisawa H: Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging. Aging Cell, 19(8): e13190, 2020. *corresponding authors.
  7. Kang S, Long K, Wang S, Sada A, Tumbar T: Histone H3 K4/9/27 trimethylation levels affect wound healing and stem cell dynamics in adult skin. Stem Cell Reports 14(1): 34-48, 2020.
  8. Changarathil G, Ramirez K, Isoda H, Sada A*, Yanagisawa H: Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis. PLoS One, 14(5): e0215908​, 2019. *corresponding author.
  9. Oinam L, Changarathil G, Ngo YX, Yanagisawa H, Sada A*: Epidermal stem cell lineages. Advances in Stem Cells and their Niches, Volume 3, 2019. *corresponding author. Invited book chapter.
  10. Tsunezumi J, Sugiura H, Oinam L, Ali A, Thang BQ, Sada A, Yamashiro Y, Kuro-O M, and Yanagisawa H: Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice. Matrix Biol 74: 5-20, 2018
  11. Sada A, Jain P, Wang S, Leung E, Tumbar T: Slc1a3-CreER as a targeting tool for the K6+ epithelial stem cell niche and its precursors during mouse hair follicle cycle. J Invest Dermatol 137(7): 1569-1571, 2017
  12. Sada A, Jacob F, Leung E, Wang S, White BS, Shalloway D and Tumbar T: Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin. Nat Cell Biol 18: 619-631, 2016. Selected for F1000 prime.
  13. Zhou Z, Shirakawa T, Ohbo K, Sada A, Wu Q, Hasegawa K, Saba R, Saga Y: RNA binding protein Nanos2 organizes post-transcriptional buffering system to retain primitive state of mouse spermatogonial stem cells. Dev Cell 34(1): 96-107, 2015
  14. Lee SE, Sada A, Zhang M, McDermitt DJ, Lu SY, Kemphues KJ and Tumbar T: High Runx1 levels promote a reversible, more-differentiated cell state in hair-follicle stem cells during quiescence. Cell Rep 6(3): 499-513, 2014
  15. Sada A and Tumbar T: New insights into mechanisms of stem cell daughter fate determination in regenerative tissues. Int Rev Cell Mol Biol 300: 1-50, 2013. Invited book chapter.
  16. Sada A, Hasegawa K, Pin PH and Saga Y: NANOS2 acts downstream of glial cell line-derived neurotrophic factor signaling to suppress differentiation of spermatogonial stem cells. Stem Cells 30(2): 280-291, 2012
  17. Suzuki H, Saba R, Sada A, Saga Y: The Nanos3-3'UTR is required for germ cell specific NANOS3 expression in mouse embryos. PLoS One 5(2): e9300, 2010
  18. Suzuki H, Sada A, Yoshida S, Saga Y: The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. Dev Biol 336(2): 222-231, 2009
  19. Sada A, Suzuki A, Suzuki H and Saga Y: The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. Science 325(5946): 1394-1398, 2009
  20. Yamasaki H, Sada A, Iwata T, Niwa T, Tomizawa M, Xanthopoulos KG, Koike T, Shiojiri N: Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development 133(21): 4233-4243, 2006