Hematopoietic Stem Cell Regulation
Dr. Nina Cabezas-Wallscheid received a MSc in Biotechnology from the University of Barcelona (Spain) and the University of Parma (Italy). She gained her PhD on the evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model at the Medical Center of Mainz (Germany) under the supervision of Dr. Ernesto Bockamp. During her PhD she spent few months as guest scientist at the laboratory of Prof. David Scadden at the Harvard Stem Cell Institute in Boston (USA). Nina conducted her postdoctoral work in the laboratory of Prof. Andreas Trumpp in the Division of Stem Cells and Cancer at the German Cancer Research Center in Heidelberg (Germany). During her postdoctoral training she uncovered molecular and functional properties of hematopoietic stem and progenitors cells by combining cutting-edge technologies including proteome, DNA methylome (TWGBS) and RNA-seq analysis at both population and single-cell level from very rare populations, combined with in vivo and in vitro functional approaches. Further, she has been investigating mechanisms involved in maintaining HSC-dormancy. In this lately study, she has found that dormant HSC properties are regulated by dietary vitamin A/ retinoic acid signaling. Nina has recently started her group at the Max Planck Institute of Immunobiology and Epigenetics (MPI-IE) in Freiburg (Germany) where she is continuing her work on how distinct dietary habits regulate hematopoietic stem cell quiescence.