◆Selected Publication

1. Akiyama T, Yasuda T, Uchihara T, Yasuda-Yoshihara N, Tan BJY, Yonemura A, Semba T, Yamasaki J, Komohara Y, Ohnishi K, Wei F, Fu L, Zhang J, Kitamura F, Yamashita K, Eto K, Iwagami S, Tsukamoto H, Umemoto T, Masuda M, Nagano O, Satou Y, Saya H, Tan P, Baba H, Ishimoto T.
   Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors.
   Cancer Res. 83(5):753-770. (2023)
2. Istiaq A, Umemoto T, Ito N, Suda T, Shimamura K, Ohta K*.
   Tsukushi proteoglycan maintains RNA splicing and developmental signaling network in GFAP-expressing subventricular zone neural stem/progenitor cells.
   Front Cell Dev Biol. 21;10:994588 (2022)
3. Takihara Y, Higaki T, Yokomizo T, Umemoto T, Ariyoshi K, Hashimoto M, Sezaki M, Takizawa H, Inoue T, Suda T, Mizuno H.
   Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells.
   Commun Biol.  5(1):776. (2022)
4. Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani JA, Tan P, Baba H, Ishimoto T.
   Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.
   Gastric Cancer., 25(3):542-557.
5. Umemoto T*, Johansson A, Ahmad SAI, Hashimoto M, Kubota S, Kikuchi K, Odaka H, Era T, Kurotaki D, Sashida G, Suda T^*. (*Corresponding author)
   ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration.
   EMBO J., 41(8):e109463.
6. Tanaka Y, Takeda R, Fukushima T, Mikami K, Tsuchiya S, Tamura M, Adachi K, Umemoto T, Asada S, Watanabe N, Morishita S, Imai M, Nagata M, Araki M, Takizawa H, Fukuyama T, Lamagna C, Masuda ES, Ito R, Goyama S, Komatsu N, Takaku T, Kitamura T.
   Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
   Nat Commun., 13(1):271 (2022)
7. Hashimoto M^#, Umemoto T^#, Nakamura-Ishizu A, Matsumura T, Yokomizo T, Sezaki M, Hino S, Takizawa H, Suda T*. (# Equally contributed)
   Autophagy is dispensable for the maintenance of hematopoietic stem cells in neonates.
   Blood Adv., 5(6):1594-1604.
8. Arima Y*, Nakagawa Y, Takeo T, Ishida T, Yamada T, Hino S, Nakao M, Hanada S, Umemoto T, Suda T, Sakuma T, Yamamoto T, Watanabe T, Nagaoka K, Tanaka Y, Kawamura YK, Tonami K, Kurihara H, Sato Y, Yamagata K, Nakamura T, Araki S, Yamamoto E, Izumiya Y, Sakamoto K, Kaikita K, Matsushita K, Nishiyama K, Nakagata N, and Tsujita K
   Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.
   Nat Metab., 3(2):196-210.
9. Endoh M*, Baba M*, Endoh T, Hirayama A, Nakamura-Ishizu A, Umemoto T, Hashimoto M, Nagashima K, Soga T, Lang M, Schmidt LS, Linehan WM, Suda T*
   A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity.
   Cell Rep., 30(6):1823-18341.e5 (2020)
10. Fukushima T, Tanaka Y*, Hamey FK, Chang CH, Oki T, Asada S, Hayashi Y, Fujino T, Yonezawa T, Takeda R, Kawabata KC, Fukuyama T, Umemoto T, Takubo K, Takizawa H, Goyama S, Ishihama Y, Honda H, Göttgens B, Kitamura T.
    Discrimination of Dormant and Active Hematopoietic Stem Cells by G₀ Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.
    Cell Rep., 29(12):4144-4158.e7 (2019)
11. Takihara Y, Nakamura-Ishizu A, Tan DQ, Fukuda M, Matsumura T, Endoh M, Arima Y, Chin DWL, Umemoto T, Hashimoto M, Mizuno H, Suda T*. 
    High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells.
    Blood Adv., 2019 3(15):2323-2327 (2019)
12. Yokomizo T*, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M, Suda T*, Komatsu N.
    Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.
    J Exp Med., 216(7):1599-1614. (2019)
13. Nakamura-Ishizu A*, Matsumura T, Stumpf PS, Umemoto T, Takizawa H, Takihara Y, O'Neil A, Majeed ABBA, MacArthur BD and Suda T *
    Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation.
    Cell Rep., 25, 1772-1785.e1776 (2018)
14. Umemoto T*, Hashimoto M, Matsumura T, Nakamura-Ishizu A, and Suda T^*. (*corresponding author)
    Ca²⁺-mitochondria axis drives cell division in hematopoietic stem cells.
    J Exp Med, 215, 2097-2113 (2018)
15. Umemoto T*, Matsuzaki, Y., Shiratsuchi, Y., Hashimoto, M., Yoshimoto, T., Nakamura-Ishizu, A., Petrich, B., Yamato, M., and Suda, T^*. (*corresponding author)
    Integrin αvβ3 enhances the suppressive effect of interferon-γ on hematopoietic stem cells.
    EMBO J, 36, 2390-2403 (2017)
16. Matsuzaki Y, Umemoto T*, Tanaka Y, Okano T, and Yamato M^* (*corresponding author)
    β2-Microglobulin is an appropriate reference gene for RT-PCR-based gene expression analysis of hematopoietic stem cells.
    Regen Ther, 1, 91-97 (2015)
17. Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K, and Okano T.
    Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells.
    Blood, 119, 83-94 (2012)
18. Umemoto T, Yamato M, Shiratsuch Y, Terasawa M, Yang J, Nishida K, Kobayash Y, and Okano T.
    Expression of Integrin beta3 is correlated to the properties of quiescent hemopoietic stem cells possessing the side population phenotype.
    J Immunol, 177, 7733-7739 (2006)
19. Umemoto T, Yamato M, Nishida K, Yang J, Tano Y, and Okano T.
    Limbal epithelial side-population cells have stem cell-like properties, including quiescent state.
    Stem Cells, 24, 86-94 (2006)