IRCMS International Research Center for Medical Sciences

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IRCMS Seminars

[Sep. 2] 68th IRCMS seminar

August 20 2020

We would like to inform you that the 68th IRCMS seminar has been scheduled as below.
We would be pleased to see many of you participating in the seminar.

Date       : September 2, 2020 (Wednesday)

Time     : 17:00-18:00

Venue    : IRCMS 1F Meeting Lounge
               * To prevent the spread of COVID-19, the seats will be limited to 15.
                 Please wear a face mask when you join.
               * This seminar will be simultaneously distributed by Zoom.

Speaker : Masahiro Ono, MD, PhD
                Senior Lecturer
                 Imperial College London
                 (Visiting Associate Professor, IRCMS)

Tilte       : Mechanisms of T cell-mediated immune regulation at the single cell level


We study temporally dynamic mechanisms underlying T cell differentiation and responses. This seminar will aim to show that, in order to understand immune regulation, it is indispensable to analyse time-dependent dynamics of the differentiation and function of individual T cells. I will discuss recent findings by single cell RNA-seq analysis, which shows that the differentiation of Treg and effector T cells is dynamically regulated in cancer microenvironments (1) and in COVID-19 patients (2). In addition, I will introduce our single-cell tool for time domain analysis, Timer of Cellular Kinetics and Activity(Tocky), and show new temporally dynamic mechanisms of T cell regulation in vivo, which was revealed by the Tocky technology (3, 4). Lastly, future perspectives will be discussed.

  1. Bradley A, Hashimoto T, and Ono M. (2018) Elucidating T cell activation-dependent mechanisms for bifurcation of regulatory and effector T cell differentiation by multidimensional and single cell analysis, Front Immunol, doi 10.3389/fimmu.2018.01444.
  2. Kalfaoglu B, Almeida-Santos J, Tye CA, Satou Y, Ono M. (2020) T-cell hyperactivation and paralysis in severe COVID-19 infection revealed by single-cell analysis. bioRxiv 2020:2020.05.26.115923. doi: 10.1101/2020.05.26.115923
  3. Bending D, Prieto-Martin P, Paduraru A, Ducker C, Marzaganov E, Laviron M, Kitano S, Miyachi H, Crompton, T, and Ono M.(2018) A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo. J Cell Biol, doi 10.1083/jcb.201711048.
  4. Bending D, Paduraru A, Prieto-Martin P, Crompton T, and Ono M (2018) A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme. EMBO J, 10.15252/embj.201899013.

Anyone in Kumamoto University who wants to join is welcome; however, please pre-register by the following URL to secure your seat / receive the Zoom meeting information.
(The seats will be secured to participants in order of registration.)

Flyer_68th IRCMS Seminar.PNG