[July 8] D5 Medical & Life Science Seminar-Dr. Koichi Takahashi

June 19 2020

The "D5 Medical & Life Science Seminar" course will be offered by International Research Center for Medical Sciences (IRCMS). It will run from April 2020 to March 2021, with lectures given by scientists who are affiliated with IRCMS or in collaboration with researchers at IRCMS. The lectures will be given once a month, in English, and by leading scientists in the relevant research field. Students will be taught: 1) how normal physiological functions are maintained in the human body; 2) how these systems become abnormal under certain pathophysiologic conditions; 3) why stem cells are important in animal development and homeostasis; 4) how stem cell-based approaches can help us understand disease mechanisms and find potential cure for diseases related to stem cell malfunction (e.g., cancer, aging).

Date       : July 8, 2020 (Wednesday)
Time      : 11:00 -
              * Zoom online seminar
               To receive the meeting ID / Password, please send an email to ircms@jimu.kumamoto-u.ac.jp with
               by July 7, 2020. Please include your name, affiliation, grade and student number in your email.
Speaker : Koichi Takahashi, M.D., Ph.D.
                Assistant Professor, The University of Texas MD Anderson Cancer Center
                Visiting Assistant Prof., IRCMS, Kumamoto University
Title        : Precision clonal mapping in acute myeloid leukemia with single-cell genomics

Abstract :

　One of the pervasive featureｘs of cancer is the diversity of mutations found in malignant cells within the same tumor, a phenomenon called clonal heterogeneity or intratumor heterogeneity. Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection inside the tumor ecosystem and is believed to contribute to treatment resistance and cancer recurrence. The ability to precisely delineate the clonal substructure of a tumor, including the evolutionary history of its development and the co-occurrence of its mutations, is necessary to understand and overcome treatment resistance. This seminar will review the current knowledge in clonal heterogeneity and evolution in cancer and how it impacts treatment of cancers. Moreover, we will go over our recent studies using the state-of-the-art single-cell methodologies to elucidate the clonal heterogeneity and evolution of acute myeloid leukemia (AML) (Morita et al. Biorxiv 2020). 

Selected publications

1. Pellegrino M, Sciambi A, Treusch S, Durruthy-Durruthy R, Gokhale K, Jacob J, Chen TX, Geis JA, Oldham W, Matthews J, Kantarjian H, Futreal PA, Patel K, Jones KW, Takahashi K, Eastburn DJ. High-throughput single-cell DNA sequencing of acute myeloid leukemia tumors with droplet microfluidics. Genome Res 28(9):1345-1352, 9/2018. e-Pub 8/2018. PMCID: PMC6120635.
2. Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, Zhang J, Heffernan TP, Gera S, Kovacs JJ, Marszalek JR, Bristow C, Yan Y, Garcia-Manero G, Kantarjian H, Vassiliou G, Futreal PA, Donehower LA, Takahashi K, Goodell MA. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell 23(5):700-713.e6, 11/2018. PMCID: PMC6224657.
3. Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics
   Kiyomi Morita1,10*, Feng Wang2*, Katharina Jahn6,7*, Tianyuan Hu8, Tomoyuki Tanaka1, Yuya Sasaki1, Jack Kuipers6,7, Sanam Loghavi3, Sa A. Wang3, Yuanqing Yan9, Ken Furudate1,11, Jairo Matthews1, Latasha Little2, Curtis Gumbs2, Jianhua Zhang2, Xingzhi Song2, Erika Thompson4, Keyur P. Patel3, Carlos E. Bueso-Ramos3, Courtney D DiNardo1, Farhad Ravandi1, Elias Jabbour1, Michael Andreeff1, Jorge Cortes1, Kapil Bhalla1, Guillermo Garcia-Manero1, Hagop Kantarjian1, Marina Konopleva1, Daisuke Nakada8, Nicholas Navin4,5, Niko Beerenwinkel6,7†, P Andrew Futreal2† and Koichi Takahashi1,2†
   Biorxiv 2020.