October 18 2019
The "D5 Medical & Life Science Seminar" course will be offered by International Research Center for Medical Sciences (IRCMS). It will run from April 2019 to March 2020, with lectures given by scientists who are affiliated with IRCMS or in collaboration with researchers at IRCMS. The lectures will be given once a month, in English, and by leading scientists in the relevant research field. Students will be taught: 1) how normal physiological functions are maintained in the human body; 2) how abnormalities in these systems (e.g., cancer) are studied using experimental models; 3) cutting-edge technologies (including single cell level imaging and omics analysis) used for mechanistic understanding of these abnormalities; 4) efforts and progresses in finding cure for human diseases associated with these abnormalities; and 5) importance of understanding disease mechanisms using cross-disciplinary approaches.
Date : November 6, 2019 (Wednesday)
Time : 17:30 -
Venue : IRCMS 1F Meeting Lounge
Speaker : Ruby Yun-Ju Huang , M.D., Ph.D.
School of Medicine, College of Medicine, National Taiwan University
(Visiting Professor, IRCMS)
Title : GRHL2: a pioneer factor
Grainyhead-like 2 (GRHL2) is an evolutionarily conserved transcription factor that regulates a repertoire of epithelial-specific genes to guard the epithelial differentiation. Grhl2 plays important roles in embryonic development. Grhl2 is expressed in the villous cytotrophoblasts and syncytiotrophoblasts in the placenta. Knocking-out of grhl2 in mice results in defects in neural tube closure and is embryonic lethal. Mutations of GRHL2 is also reported in human diseases such as Autosomal-Recessive Ectodermal Dysplasia Syndrome. GHRL2 has been shown to suppress epithelial-mesenchymal transition (EMT). The loss of GRHL2 results in sequential changes in the EMT phenotype. More recently, GRHL2 has been suggested to act as a pioneer factor. In this lecture, I will introduce the findings from the literatures to support the role of GRHL2 as a pioneer factor during epithelial differentiation.