[July 10] D5 Medical & Life Science Seminar - Dr. Yosuke Mukoyama

June 7 2019

 The "D5 Medical & Life Science Seminar" course will be offered by International Research Center for Medical Sciences (IRCMS). It will run from April 2019 to March 2020, with lectures given by scientists who are affiliated with IRCMS or in collaboration with researchers at IRCMS. The lectures will be given once a month, in English, and by leading scientists in the relevant research field. Students will be taught: 1) how normal physiological functions are maintained in the human body; 2) how abnormalities in these systems (e.g., cancer) are studied using experimental models; 3) cutting-edge technologies (including single cell level imaging and omics analysis) used for mechanistic understanding of these abnormalities; 4) efforts and progresses in finding cure for human diseases associated with these abnormalities; and 5) importance of understanding disease mechanisms using cross-disciplinary approaches.

Date       : July 10, 2019 (Wednesday) 

Time      : 17:30 - ⇒　16:30 -

Venue    : IRCMS 1F Meeting Lounge

Speaker : Yosuke Mukoyama, Ph.D.
                Senior Investigator,
                Cell and Developmental Biology Center,
                NHLBI,NIH (Visiting Prof., IRCMS)

Title        : Macrophage control of brain development

Abstract :

There is a burgeoning interest in the ontogeny and differentiation capacities of the tissue-localized macrophage lineage that is born in the yolk sac (YS) (Ginhoux et al. Science 2010; Kierdorf et al. Nat Neurosci 2013; Gomez Perdiguero et al. Nature 2015). The timely colonization of YS-derived macrophages in the neural tube, which comprises the brain and spinal cord of the central nervous system (CNS), coincides with early CNS neurogenesis.  Yet, it remains unclear whether CNS macrophages direct neural stem cells and progenitors to influence brain development during embryogenesis and whether dysfunction or depletion of CNS macrophages causes congenital neurological disorders such as cortical malformation.Our work employs a combination of high-throughput RNA sequencing, high-resolution imaging, and genetic manipulations to determine how embryonic CNS macrophages influence brain development at single-cell resolution.