January 21 2019
The "D5 Medical & Life Science Seminar" course will be offered by International Research Center for Medical Sciences (IRCMS). It will run from May 2018 to March 2019, with lectures given by scientists affiliated or collaborated with the IRCMS. The course theme for this academic year is "Basic research for understanding disease mechanisms". The lectures will be given once a month, in English, and by leading scientists in the relevant research field. Students will be taught: 1) how normal physiological functions are maintained in human hematopoietic, vascular, immune, reproductive and nervous tissues and organs; 2) how abnormalities in these systems (e.g., cancer) are studied using experimental models; 3) cutting-edge technologies (including single cell level imaging and omics analysis) used for mechanistic understanding of these abnormalities; 4) efforts and progresses in finding cure for human diseases associated with these abnormalities; and 5) importance of understanding disease mechanisms using
Date : February 6, 2019 (Wed)
Time : 17:30 -
Venue : IRCMS 1F Meeting Lounge
Speaker : Hidenobu Mizuno, Ph.D.
Title :In vivo imaging to understand the mechanisms of brain disorders
Higher functions of the brain rely on the formation of precise neuronal circuit during development. To understand the process and mechanisms of the circuit formation in living animal, we have been using in vivo two-photon time-lapse imaging technique. We previously found that neuronal dendrites in the mouse cerebral cortex are highly motile during the period of circuit formation. However the molecular mechanisms controlling dendritic dynamics and circuit formation are still largely unknown. By using a novel plasmid vector-based gene silencing system, we have been screening the genes involved in the circuit formation in living animal. During screening, we found a gene which is related with a brain disorder. In this seminar, I would like to discuss the role of the brain disease-related gene in the neuronal circuit formation.