July 11 2017
We would like to inform you that the "D5 Medical & Life Science Seminar AY 2017 D5 「International Biomedical Research Seminars」" has been scheduled as below. We would be pleased to see many of you participating in the seminar.
Date: July 11, 2017 (Tue) Time: 17:30 -
Venue: IRCMS 1F Meeting Lounge
Speaker: Yosuke MUKOYAMA Ph.D.
Genetics and Developmental Biology Center
National Heart, Lung, and Blood Institute National Institutes of Health, U.S.A.
(Visiting Professor, IRCMS, JAPAN)
"Building Heart and Circulatory System: New Questions and Paradigms"
The formation of the heart and vasculature during embryogenesis is a miraculous event in which the lateral plate mesoderm gives rise to distinct progenitors to coordinately generate the heart, blood vessels, and blood cells of the circulatory system. Emerging evidence suggests that their cellular components are "heterogeneous" in origin. Heterogeneous cardiomyocyte populations are derived from distinct sets of cardiac precursor cells. Coronary arterial endothelial cells are derived from two distinct cardiac tissues: the sinus venosus and ventricular endocardium. Our recent findings indicate that the developmental sources of pericytes, the mural cells of blood capillaries, are heterogeneous: some pericytes are derived from myeloid progenitors in the ectoderm-derived brain and skin. Recent studies in mice and fish including a state-of-art Cre/LoxP-based lineage tracing approach will be discussed. Insight into the heterogeneous origins and developmental processes of the heart and vasculature has important implications for understanding congenital heart and vascular diseases.