【Books/review/comments】Microbiome and Hemato-immune Aging

December 11 2024

Labs: Hitoshi Takizawa

Paper information

Title:

Microbiome and Hemato-immune Aging

Alban Johansson, Nicole Pui-Yu Ho, Hitoshi Takizawa

Experimental Hematology 22 November 2024.  doi: https://doi.org/10.1016/j.exphem.2024.104685

Highlights:

• Microbiome changes throughout life and affects the hemato-immune system.
• Dysbiosis promotes hemato-immune aging via enhanced inflammatory tissue environment.
• Dominance of specific microbiota correlates with worse outcome in hematologic malignancies, allogeneic hematopoietic stem cell transplantation, and graft-versus-host disease.
• Fecal microbiota transplantation, probiotics, and bacteriophages present alternative therapeutic strategies to target microbiota.

Abstract:

Microbiome is a highly complex and diverse symbiotic component that undergoes dynamic changes with the organismal aging. Microbial perturbations, termed dysbiosis, exert strong influence on dysregulating the bone marrow niche and subsequently promoting the aging of hematopoietic and immune system. Besides, accumulating studies have revealed the substantial impact of intestinal microbiome on the initiation and progression of age-related hematologic alteration and diseases, such as clonal hematopoiesis and blood cancers. Current therapeutic approaches to restore the altered microbiome diversity target specific pathobionts and are demonstrated to improve clinical outcomes of anti-hematologic malignancy treatments. In this review, we discuss the interplay between the microbiome and the hemato-immune system during aging process. We also shed light on the emerging therapeutic strategies to tackle the dysbiosis for amelioration of aging and disease progression.