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Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails

September 11 2020

Toshio Suda

Authors: Ayako Nakamura-Ishizu,Shah Adil Ishtiyaq Ahmad,Toshio Suda

Title: Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails

Trends in Cell Biology

https://doi.org/10.1016/j.tcb.2020.08.006

Abstract:
The transplantation of healthy hematopoietic stem cells (HSCs) contained in the bone marrow is a frontline treatment option for hematopoietic diseases. Detailed analysis of post-transplant HSC kinetics is crucial as the initial engraftment of HSCs influences prognosis. Dong et al. have explored the dynamic change in HSC cell fate upon bone marrow transplantation through the utilization of single-cell transcriptomic analysis.

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Keywords:
hematopoietic stem; bone marrow transplantation; progenitors; clonal dynamics