IRCMS International Research Center for Medical Sciences

Research

Hitoshi Takizawa
Ph.D.
Professor (Vice Director)

ACHIEVEMENT

Selected publications
  1. Sezaki M#, Hayashi Y#, Wang Y, Johansson A, Umemoto T, Takizawa H*, Immuno-modulation of hematopoietic stem and progenitor cells in inflammation, Front Immunol., in press
  2. Morishima T*, Takizawa H*. Genetic fingerprint defines hematopoietic stem cell pool size and function. Haematologica, 2020 Mar;105(3):526-528. doi: 10.3324/haematol.2019.241299. No abstract available. PMID: 32115410
  3. Bourgine PE, Fritsch K, Pigeot S, Takizawa H, Kunz L, Kokkaliaris KD, Coutu DL, Manz MG*, Martin I*, Schroeder T*. Fate distribution and regulatory role of human mesenchymal stromal cells in engineered hematopoietic bone organs. iScience. 2019 Sep 27;19:504-513
  4. Fritsch K, Pigeot S, Bourgine PE, Feng X, Schroeder T, Martin I, Manz MG, Takizawa H*, Engineered humanized bone organs maintain human hematopoiesis in vivo, Exp Hematol., 2018 May;61:45-51
  5. Takizawa H*, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz Á, Nombela-Arrieta C and Manz MG.
    Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness. Cell Stem Cell, 2017 Jul 19. pii: S1934-5909(17)30239-4. doi: 10.1016/j.stem.2017.06.013. *correspondence
  6. Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H*.
    Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells and the Bone Marrow Microenvironment. Front Immunol, 2016, Nov 14;7;502. eCollection 2016
  7. Kovtonyuk LV, Manz MG, Takizawa H*. Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo. Blood, 2016 Jun 23;127(25):3175-9.
  8. Lundberg P#Takizawa H#, Kubovcakova L#, Guo G, Hao-Shen H, Dirnhofer S, Orkin SH, Manz MG, Skoda RC. Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F J Exp Med., 2014 Oct 20;211(11):2213-30., #equal contribution
  9. Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG. Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine. Annu Rev Immunol., 2013 Jan 16, 2013 Mar 5;110(10):3997-4002.
  10. Scotti C#, Piccinini E#Takizawa H#, Todorov A, Bourgine P, Papadimitropoulos A, Barbero A, Manz MG, Martin I. Engineering of a functional bone organ through endochondral ossification. Proc Natl Acad Sci U S A., 2013, Mar 5;110(10):3997-4002, #equal contribution
  11. Takizawa H, Boettcher S, Manz MG. Demand-adapted regulation of early hematopoiesis in infection and inflammation. Blood., 2012 Mar 29;119(13):2991-3002.
  12. Takizawa H#, Regoes RR#, Boddupalli CS, Bonhoeffer S, Manz MG. Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation. J Exp Med., 2011 Feb; 14;208(2):273-84., #equal contribution
  13. Takizawa H#, Nishimura S#, Nishikii H, Takayama N, Oda A, Kakinuma S, Morita Y, Yamazaki S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu Ki, Nakauchi H, Takaki S, Eto K. Lnk/Sh2b3 regulates integrin αIIbβ3 outside in signaling in platelets leading to stabilization of developing thrombus in vivo. J Clin Invest., 2010 Jan;120(1):179-90., #equal contribution
  14. Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, Takaki S, Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals. Exp Hematol., 2008 Jul; 36(7): 897-906
  15. Takizawa H, Manz MG, Macrophage tolerance: CD47-SIRP-alpha-mediated signals matter. Nat Immunol., 2007 Dec; 8(12): 1287-9.
  16. Takizawa H, Kubo-Akashi C, Nobuhisa I, Kwon SM, Iseki M, Taga T, Takatsu K, Takaki S. Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk. Blood., 2006 Apr 1; 107(7): 2968-75.

    For complete list of publications, please refere to the link.

Awards
2020 Healthy Longevity Grand Challenge Catalysis Award, The United States National Academy of Science
2019 Interstellar Initiative, Japan Agency of Medical Research and Development
2013 Bruno Speck Award, Basel Stem Cell Network
2013 Basic Science Award, 39th Annual meeting of the European Group For Blood and Marrow Transplantation
2009 Young Investigator Award, 2nd International Workshop on Humanized Mice