Lab: Hitoshi Takizawa
Hematopoietic stem and progenitor cells integrate microbial signals to promote post-inflammation gut tissue repair
Maiko Sezaki, Yoshikazu Hayashi, Gaku Nakato, Yuxin Wang, Sayuri Nakata, Subinoy Biswas, Tatsuya Morishima, Md Fakruddin, Jieun Moon, Soyeon Ahn, Pilhan Kim, Yuji Miyamoto, Hideo Baba, Shinji Fukuda, Hitoshi Takizawa
The EMBO Journal (2022)e110712 doi:10.15252/embj.2022110712 URL: https://doi.org/10.15252/embj.2022110712
Bone marrow (BM)-resident hematopoietic stem and progenitorcells (HSPCs) are often activated following bacterial insults toreplenish the host hemato-immune system, but how they integratethe associated tissue damage signals to initiate distal tissue repairis largely unknown. Here, we show that acute gut inflammationexpands HSPCs in the BM and directs them to inflamed mesentericlymph nodes through GM-CSFR activation for further expansionand potential differentiation into Ly6C+/G+myeloid cells special-ized in gut tissue repair. We identified this process to be mediatedbyBacteroides, a commensal gram-negative bacteria that activatesinnate immune signaling. These findings establish cross-organcommunication between the BM and distant inflamed sites,whereby a certain subset of multipotent progenitors is specified torespond to imminent hematopoietic demands and to alleviateinflammatory symptoms.