October 27 2021
Lab: Takatsugu Ishimoto
Cellular senescence in the tumor microenvironment and context-specific cancer treatment strategies
Yasuda T, Baba H, Ishimoto T*.
FEBS J. 2021 Oct 15.
Cellular senescence in cancer development is known to have tumor-suppressive and tumor-promoting roles. Recent studies have revealed numerous molecular mechanisms of senescence followed by SASP induction and showed the significance of senescence on both sides. Cellular senescence in stromal cells is one of the reasons for therapeutic resistance in advanced cancer; thus, it is an inevitable phenomenon to address while seeking an effective cancer treatment strategy. This review summarizes the molecular mechanisms regarding cellular senescence, focusing on the dual roles played by senescence, and offers some direction toward successful treatments targeting harmful senescent cells.