Cellular senescence in the tumor microenvironment and context-specific cancer treatment strategies

October 27 2021

Lab: Takatsugu Ishimoto

Paper information

Title:
Cellular senescence in the tumor microenvironment and context-specific cancer treatment strategies

Yasuda T, Baba H, Ishimoto T*.

(*corresponding author)

FEBS J. 2021 Oct 15.

doi: 10.1111/febs.16231. 

Summary

Cellular senescence in cancer development is known to have tumor-suppressive and tumor-promoting roles. Recent studies have revealed numerous molecular mechanisms of senescence followed by SASP induction and showed the significance of senescence on both sides. Cellular senescence in stromal cells is one of the reasons for therapeutic resistance in advanced cancer; thus, it is an inevitable phenomenon to address while seeking an effective cancer treatment strategy. This review summarizes the molecular mechanisms regarding cellular senescence, focusing on the dual roles played by senescence, and offers some direction toward successful treatments targeting harmful senescent cells.