[Nov. 27] 131st IRCMS Seminar

October 21 2025

We would like to inform you that the 131st IRCMS seminar has been scheduled as below.
* This IRCMS seminar is open to everyone.

Date      : November 27, 2025 (Friday)

Time      : 16:00-17:00

ZOOM　: Meeting ID: 959 4672 4619 
            　 Passcode: Sem27Nov

Speaker : Dr. Yosuke Mukoyama (National Institutes of Health,US)

Title        : Imaging Neuro-Vascular Dysfunction

Abstract:

We are committed to understanding the intricate interactions between the nervous and vascular systems, both during development and in the context of disease, considering their shared anatomical characteristics and coordinated patterning. In this study, we examine neuro-vascular dysfunction in obesity-affected skin as a pathological setting. Obesity often leads to vascular abnormalities and sensory nerve dysfunction known as neuropathy. Yet, the link between these two phenomena has remained elusive. To address this issue, we employed high-resolution imaging to analyze both structural and functional changes in mouse models of diet-induced obesity (DIO). Our studies revealed notable changes in the skin superficial capillary plexus of the skin in DIO mice, where we observed fenestration resulting in capillary hyperpermeability. Simultaneously, we observed that peripheral sensory nerves in the skin epidermis of DIO mice showed an exaggerated response to pain stimuli, indicating that these mice experienced neuropathic pain in the skin. Interestingly, our efforts to manage capillary hyperpermeability effectively alleviated neuropathic pain in these mice. These findings present a compelling opportunity: by targeting skin capillary leakage, we can control the diffusion of key soluble factors from the microcirculation and potentially manage obesity-mediated neuropathic pain.

Major papers:

1.    Koui Y, Song S, Dong, X, Mukouyama YS. (2025) Local keratinocyte-nociceptor interactions enhance obesity-mediated painful small fiber neuropathy via NGF-TrkA-PI3K signaling axis. iScience 28: 112047.

PMID: 40160426, bioRxiv. PMID: 39372742 

2.     Yamazaki T, Li W, Yang L, Li P, Cao H, Motegi SI, Udey MC, Bernhard E, Nakamura T, Mukouyama YS (2018) Whole-mount adult ear skin imaging reveals defective neuro-vascular branching morphogenesis in obese and type 2 diabetic mouse models. Scientific Reports 8: 430.

PMID: 29323138

Flyer: (Click to enlarge)