[May. 15] 123rd IRCMS Seminar

April 23 2025

We would like to inform you that the 123rd IRCMS seminar has been scheduled as below.
* This IRCMS seminar is open to everyone.

Date      : May 15, 2025 (Thursday)

Time      : 16:00-17:00

ZOOM　: Meeting ID: 923 3251 6080
            　Passcode: Sem15May

Speaker : Dr. Gabriele G. Schiattarella (Charité-Universitätsmedizin Berlin / Max Delbrück Center)

Title        : Decoding Cardiometabolic HFpEF

Abstract 

The prevalence of chronic metabolic diseases like obesity, metabolic syndrome, and diabetes, along with cardiovascular multi-comorbidities, has significantly increased. These conditions, collectively known as cardiometabolic diseases (CMDs), are the leading cause of mortality, responsible for 31% of global deaths. Among CMDs, heart failure with preserved ejection fraction (HFpEF), particularly the cardiometabolic (obese) HFpEF phenotype, is rapidly becoming the most common form of heart failure. Despite its rising prevalence, effective therapies remain limited. There is an urgent need to uncover novel mechanisms, including the role of interorgan crosstalk, in HFpEF pathogenesis.

2-3 major papers:

1. Strocchi S. LL, Wang R., Häseli SP, Capone F, Bode D, Nambiar N, Eroglu T, Santiago Padilla L, Farrelly C, Vacca A, Mascagni M, Oeing CU, Kintscher U, Jung S. Diezel SA, Liévano Contreras SV, Zhou M, Seldin M, Schiattarella GG*. Systems Biology Approach Uncovers Candidates for Liver-Heart Interorgan Crosstalk in HFpEF. Circulation Research 2024; Aug 29. doi: 10.1161/CIRCRESAHA.124.324829. *Corresponding author Journal Issue Cover

2. Schiattarella GG, Altamirano F, Kim SY, Tong D, Ferdous A, Piristine H, Dasgupta S, Wang X, French KM, Villalobos E, Spurgin SB, Waldman M, Jiang N, May HI, Hill TM, Luo X, Yoo H, Zaha VG, Lavandero S, Gillette TG, Hill JA. Xbp1s-FoxO1 Axis Governs Lipid Accumulation and Contractile Performance in Heart Failure with Preserved Ejection Fraction. Nature Communications. 2021 Mar 16;12(1):1684.

3. Schiattarella GG, Altamirano F, Tong D, French KM, Villalobos E, Kim SY, Luo X, Jiang N, May HI, Wang ZV, Hill TM, Mammen PPA, Huang J, Lee DI, Hahn V, Sharma K, Kass DA, Lavandero S, Gillette TG, Hill JA. Nitrosative Stress Drives Heart Failure with Preserved Ejection Fraction. Nature. 2019 Apr;568(7752):351-356.
Highlighted in: Amgalan D, Kitsis RN. Nature. 2019 Apr;568(7752):324-325.
Highlighted in: Lim GB. Nature Review Cardiology. 2019 Apr 24
Highlighted in: Paulus WJ. New England Journal Medicine 2020 Feb 13;382(7):679-682

Flyer: (Click to enlarge)