[Jan. 29] D5 Seminar-Dr. Robert Signer (University of California)

January 21 2025

The "D5 Medical & Life Science Seminar" course will be offered by International Research Center for Medical Sciences (IRCMS). It will run from May 2024 to March 2025, with lectures given by scientists who are affiliated with IRCMS or in collaboration with researchers at IRCMS. The lectures will be given once a month, in English, and by leading scientists in the relevant research field. Students will be taught: 1) how normal physiological functions are maintained in the human body; 2) how these systems become abnormal under certain pathophysiologic conditions; 3) why stem cells are important in animal development and homeostasis; 4) how stem cell-based approaches can help us understand disease mechanisms and find potential cure for diseases related to stem cell malfunction (e.g., cancer, aging).

Anyone who wants to join is welcome.
For students who have registered for the course, please check your attendance in Moodle.

Date      : January 29, 2025 (Wednesday)
               

Format  : Online

Time      : 12:00 - 13:00 (JST)
               

Speaker : Dr. Robert Signer (University of California)
               

Title       : Stem Cell Fitness & Longevity: The Role of Proteostasis

Major Papers:

1. Bernadette A Chua, Connor J Lennan, et al. Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis. Cell Stem Cell. 2023 Apr 6;30(4):460-472.e6. doi: 10.1016/j.stem.2023.02.010. Epub 2023 Mar 21.

2. Lorena Hidalgo San Jose, Mary Jean Sunshine, et al. Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.

Cell Rep. 2020 Jan 7;30(1):69-80.e6. doi: 10.1016/j.celrep.2019.12.003.

3. Robert A J Signer, Jeffrey A Magee, et al. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014 May 1;509(7498):49-54. doi: 10.1038/nature13035. Epub 2014 Mar 9.