[May 16] 110th IRCMS Seminar

May 7 2024

We would like to inform you that the 110th IRCMS seminar has been scheduled as below.
* This IRCMS seminar is open to everyone.

Date      : May 16, 2024 (Thursday)

Time      : 13:30-14:30

ZOOM　: Meeting ID: 937 7155 3206
            　 Passcode: 110Seminar

Speaker : Dr. Norika Liu (IRCMS)

Title        : New insights into the role and origin of cardiac macrophages

Abstract 

The cells that comprise the circulatory system not only share their origins but also mutually promote each other's differentiation during the formation of functional circulatory system. We previously reported a subset of endocardial cells is hemogenic during early embryogenesis. They are enriched in the cushion region, the primordia of the cardiac valves and septa, where active remodeling via endothelial-mesenchymal transition takes place. Thus, the remodeling sites spatiotemporally coincide with embryonic hematopoietic sites for unknown reason. In our latest publication (Liu et al, Nat. Commun. 2023), we showed that both EndoMT (endothelial-to-mesenchymat transition) and EHT (endothelial-to-hematopoietic transition) are regulated by Nkx2-5-Notch signaling, suggesting that Drosophila tinman-dependent cardio-hematopoietic program is conserved in mammals. Following EHT, we demonstrated that suppression of retinoic acid levels via Dhrs3 expression is essential for macrophage differentiation and contributes to local tissue remodeling. These findings on the mechanisms of transcriptional regulation provide insight into why hematopoiesis is spatiotemporally consistent with tissue remodeling and the significance of local endocardial hematopoiesis. The talk will include the latest findings on the specific role of endocardially-derived tissue macrophages.

Flyer: (Click to enlarge)