[Apr. 26] 107th IRCMS Seminar

April 3 2024

We would like to inform you that the 107th IRCMS seminar has been scheduled as below.
* This IRCMS seminar is open to everyone.

Date      : April 26, 2024 (Friday)

Time      : 16:00-17:00

ZOOM　: Meeting ID:842 2428 2979
            　Passcode: Semi24Apri

Speaker : Dr. Ichiro Manabe (Chiba University)

Title        : Hematoimmune stress memory in heart failure and multimorbidity

Abstract :

Multimorbidity is a rapidly growing medical and societal challenge, reflecting in part the aging of society. Heart failure is one of the key diseases of multimorbidity, causing multiple comorbidities including chronic kidney disease, frailty, depression and cancer. In addition, hospitalization for heart failure is a major future risk for disease recurrence and worsening. While these suggest close links between the pathologies, how heart failure increases the future risk of its comorbidities and itself is poorly understood. We found that macrophages are essential for maintaining cardiac homeostasis and play a critical role in organ crosstalk in multimorbidity. For example, we have previously shown that cardiac macrophages are regulated by the heart-brain-kidney organ network and play a critical role in the cardiac adaptive response to pressure overload. However, they can also promote cardiac pathology. In this talk, I will show that heart failure inscribes an epigenetic memory in hematopoietic stem/progenitor cells that alters the differentiation trajectory and function of progeny macrophages, leading to cardiac remodeling and heart failure.

1.  Hayakawa S, Tamura A, Nikiforov N, Koike H, Kudo F, Cheng Y, Miyazaki T, Kubekina M, Kirichenko TV, Orekhov AN, Yui N, *Manabe I, Oishi Y. Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling. JCI Insight 22:e138539, 2022.
2.  Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, Liu Y, Maru Y, Hasumi E, Kojima T, Seno H, Asano K, Ishijima A, Tomii N, Yamazaki M, Kudo F, Sakuma I, Nagai R, *Manabe I, Komuro I.Cardiac macrophages prevent sudden death during heart stress. Nat Commun 12:1910, 2021.
3.  Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, *Manabe I. A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation and cellular communication. Nat Med 23:611-622, 2017.

Flyer: (Click to enlarge)