September 1 2023
We would like to inform you that the 94th IRCMS seminar has been scheduled as below.
* This IRCMS seminar is open to everyone.
Date : September 14, 2023 (Thursday)
Time : 16:00-17:00
ZOOM : Meeting ID: 884 5562 8103
Speaker : Dr. Takumi Maruhashi
University of Tokyo
Title : Immune regulation by LAG-3, a unique inhibitory co-receptor
Lymphocyte-activation gene 3 (LAG-3), an inhibitory co-receptor, plays a key role in the regulation of autoimmunity, tumor immunity and infectious immunity. LAG-3 attracts increasing interest as a therapeutic target beyond PD-1 and CTLA-4, whereas many of the basic properties of LAG-3, such as ligand specificity and inhibitory mechanisms, remain unelucidated. Although LAG-3 has been reported to bind to MHC class II, we found that LAG-3 did not recognize MHC class II universally but instead selectively recognizes conformationally stable complexes of peptides and MHC class II (pMHCII). Thereby, LAG-3 selectively suppressed the activation of CD4+ T cells responsive to stable but not unstable pMHCII to suppress autoimmunity and anti-cancer immunity, and the inhibitory effect was mediated through its cytoplasmic region. In this seminar, I will introduce these recent studies demonstrating a unique property of LAG-3 as an immunoinhibitory co-receptor.
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