[ August 18th ] Joint Invited Speaker Seminar Series for Future Medicine

July 6 2022

The "Joint Invited Speaker Seminar Series for Future Medicine" will be co-hosted by Korea Advanced Institute of Science and Technology (KAIST) GSMSE and International Research Center for Medical Sciences (IRCMS). It will run from May 2022 to September 2022, with lecture given by scientists who are affiliated with IRCMS or in collaboration with reseachers at IRCMS. The lectures will be given three times a month, in English, and by leading scientists in the relevant research field.

Date : August 18th (Thu)

Time : 17:00 (JST)

Speaker : Dr. Min-Kyu Yum
                Cambridge University

Title : Tracing oncogene-driven paracrine remodelling of the intestinal stem cell niche

Abstract:

Interactions between tumor cells and the surrounding microenvironment contribute to tumor progression, metastasis and recurrence. Here, I present an oncogene-associated, multicolor reporter mouse model, the Red2Onco system, that allows differential tracing of mutant and wild-type cells in the same tissue. Applied to the small intestine, I showed that oncogene-expressing mutant crypts alter the cellular organization of neighboring wild-type crypts, driving accelerated clonal drift. Crypts expressing oncogenic KRAS or PI3K secrete BMP ligands that suppress local stem cell activity, while induced changes in PDGFRlo CD81+ stromal cells by crypts with oncogenic PI3K alter the Wnt signaling environment. Together, these results show how oncogene-driven paracrine remodeling creates a niche environment that is detrimental to the maintenance of wild-type tissue, promoting field transformation dominated by oncogenic clones.

This seminar will be held via Zoom.
Please register at the link below if you would like to participate.
https://docs.google.com/forms/d/e/1FAIpQLSenZyyWw2h4XA4GhJUwaoMbZb95CNstqAFWcWkHiN451rDwMg/viewform?usp=sf_link