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[ May.18] D5 Medical & Life Science Seminar-Dr.Miki Ebisuya EMBL Barcelona

May 2 2022

The "D5 Medical & Life Science Seminar" course will be offered by International Research Center for Medical Sciences (IRCMS). It will run from May 2022 to March 2023, with lectures given by scientists who are affiliated with IRCMS or in collaboration with researchers at IRCMS. The lectures will be given once a month, in English, and by leading scientists in the relevant research field. Students will be taught: 1) how normal physiological functions are maintained in the human body; 2) how these systems become abnormal under certain pathophysiologic conditions; 3) why stem cells are important in animal development and homeostasis; 4) how stem cell-based approaches can help us understand disease mechanisms and find potential cure for diseases related to stem cell malfunction (e.g., cancer, aging).

Date      : May 18, 2022 (Wednesday)

Time      : 16:00 -

              * Zoom online seminar

To receive the meeting ID / Password, please send an email to

ircms* by 12:00 on May 18, 2022.

(Replace * with @ when you send an email.)Please include your name, affiliation, grade and student number in your email.

Speaker :Dr. Miki Ebisuya EMBL Barcelona

Title        : SYNTHETIC DEVELOPMENTAL BIOLOGY: Cross-species comparison and manipulation of organoids

While mechanisms of embryonic development are well conserved among mammals, the progression speed tends to be slower in larger species. To study differences in time between species, my group uses in vitro systems. We have recently recapitulated the segmentation clock, oscillatory gene expression during early development, from human and mouse pluripotent stem cells. The oscillation period of the human segmentation clock is 5-6 hours, while the mouse period is 2-3 hours. We found that this period difference between species stems from slower biochemical reactions in human cells, including slower protein degradation and longer delays in gene expression processes. Now we are extending this approach of cross-species comparison to other mammalian species, including cows and rhinos, and other developmental processes. In parallel, we develop genetic tools to manipulate developmental processes and organoids.


Selected publications

1.Matsuda et al, Science, 369, 1450-1455 (2020).
2.Matsuda et al, Nature, 580, 124-129 (2020).
3.Martinez-Ara et al, bioRxiv, doi: (2021).