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[June 16] D5 Medical & Life Science Seminar-Dr. Masayo Takahashi

May 31 2021

The "D5 Medical & Life Science Seminar" course will be offered by International Research Center for Medical Sciences (IRCMS). It will run from April 2021 to March 2022, with lectures given by scientists who are affiliated with IRCMS or in collaboration with researchers at IRCMS. The lectures will be given once a month, in English, and by leading scientists in the relevant research field. Students will be taught: 1) how normal physiological functions are maintained in the human body; 2) how these systems become abnormal under certain pathophysiologic conditions; 3) why stem cells are important in animal development and homeostasis; 4) how stem cell-based approaches can help us understand disease mechanisms and find potential cure for diseases related to stem cell malfunction (e.g., cancer, aging).

Date      : June 16, 2021 (Wednesday)

Time      : 16:30 -
              * Zoom online seminar

To receive the meeting ID / Password, please send an email to
ircms* by 15:30 on June 16, 2021.
(Replace * with @ when you send an email.)
Please include your name, affiliation, grade and student number in your email.

Speaker : Masayo Takahashi, MD, PhD
                Vision Care Inc. & Kobe Eye Center Hospital

Title        : Retinal Organoid Transplantation

Abstract :

 Our aim is to develop outer retinal cell therapy using iPS cells. The first in man application of iPS cells started in 2013, targeted age-related macular degeneration. First autologous iPS-derived retinal pigment epithelial (RPE) cell transplantation and then we proceeded to clinical research using HLA matched allogeneic iPSC-derived RPE cells from 2017. Immune responses to transplanted allogeneic cells could be controled by topical steroid administration without systemic immunosuppressant. Safety of iPS-derived RPE was confirmed with those clinical studies.

 The next challenge is photoreceptor replacement. iPSC-retinal organoid transplantation is a promising treatment to restore visual function to degenerated retinas. We proved that (1) the grafted immature retinal sheet maturated after transplantation in the eye. (2) grafted photoreceptor cells could form synapses with host secondary neurons in photoreceptor degenerated adult mice. (3) MEA (multielectrode array) recording showed that grafted cells could elicit light responses in the host ganglion cells. (4) The blinded mice could react to the light stimuli in the behavior test after transplantation. With those findings as POC, we performed clinical study using retinal organoid for retinitis pigmentosa for two patients.

 I will talk about the current status and future vision of retinal cell therapy.

Selected publications:

  1. Ochiai K, Motozawa N, Terada M, et al.
    A variable-scheduling maintenance culture platform for mammalian cells
    SLAS Technology (2020) doi: 10.1177/2472630320972109
  2. Mandai M, Watanabe A, Kurimoto Y, et al.
    Autologous induced stem-cell-derived retinal cells for macular degeneration.
    The New England Journal of Medicine 376. 1038-1046 (2017) doi:10.1056/NEJMoa1608368
  3. Mandai M, Fujii M, Hashiguchi T, et al.
    iPSC-derived retinal transplants improve vision in rd1 end-stage retinal degeneration mice.
    Stem Cell Reports 8. 69-83 (2017) doi:10.1016/j.stemcr.2016.12.008
  4. Sugita S,Iwasaki Y, Makabe K, et al.
    Successful transplantation of retinal pigment epithelial cells from MHC homozygote iPSCs in MHC-matched models.
    Stem Cell Reports 7(4). 635-648. (2016) doi:10.1016/j.stemcr.2016.08.010
  5. Shirai H, Mandai M, Matsushita K, et al.
    Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.
    Proceedings of the National Academy of Sciences of the United States of America 113(1). E81-90 (2016) doi:10.1073/pnas.1512590113
  6. Jin ZB, Okamoto S, Osakada F, et al.
    Modeling retinal degeneration using patient-specific induced pluripotent stem cells.
    PLoS One 6. e17084 (2011) doi:10.1371/journal.pone.0017084

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