June 19 2020
The "D5 Medical & Life Science Seminar" course will be offered by International Research Center for Medical Sciences (IRCMS). It will run from April 2020 to March 2021, with lectures given by scientists who are affiliated with IRCMS or in collaboration with researchers at IRCMS. The lectures will be given once a month, in English, and by leading scientists in the relevant research field. Students will be taught: 1) how normal physiological functions are maintained in the human body; 2) how these systems become abnormal under certain pathophysiologic conditions; 3) why stem cells are important in animal development and homeostasis; 4) how stem cell-based approaches can help us understand disease mechanisms and find potential cure for diseases related to stem cell malfunction (e.g., cancer, aging).
Date : July 8, 2020 (Wednesday)
Time : 11:00 -
* Zoom online seminar
To receive the meeting ID / Password, please send an email to email@example.com with
by July 7, 2020. Please include your name, affiliation, grade and student number in your email.
Speaker : Koichi Takahashi, M.D., Ph.D.
Assistant Professor, The University of Texas MD Anderson Cancer Center
Visiting Assistant Prof., IRCMS, Kumamoto University
Title : Precision clonal mapping in acute myeloid leukemia with single-cell genomics
One of the pervasive featureｘs of cancer is the diversity of mutations found in malignant cells within the same tumor, a phenomenon called clonal heterogeneity or intratumor heterogeneity. Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection inside the tumor ecosystem and is believed to contribute to treatment resistance and cancer recurrence. The ability to precisely delineate the clonal substructure of a tumor, including the evolutionary history of its development and the co-occurrence of its mutations, is necessary to understand and overcome treatment resistance. This seminar will review the current knowledge in clonal heterogeneity and evolution in cancer and how it impacts treatment of cancers. Moreover, we will go over our recent studies using the state-of-the-art single-cell methodologies to elucidate the clonal heterogeneity and evolution of acute myeloid leukemia (AML) (Morita et al. Biorxiv 2020).