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[Mar. 25] 79th IRCMS seminar

March 23 2022

We would like to inform you that the 77th IRCMS seminar has been scheduled as below. We would be pleased to see many of you participating in the seminar.

Date       : March 25, 2022 (Friday)

Time     : 16:00-17:00
               * On-site and Online
               * To prevent the spread of COVID-19, the seats will be limited to 20.

Speaker : Toshimi Yoshida, PhD
                Cutaneous Biology Research Center,
                Massachusetts General Hospital,
                Harvard Medical School

Tilte       : The role of epigenetic regulators in early hematopoiesis


Changing access of nuclear factors to developmentally regulated genes is a key mechanism in differentiation. Chromatin accessibility is controlled by enzymes that change chromatin structures by unwinding chromatin fibers, modifying histones and remodeling nucleosomes. Mi-2beta (Chd4) is a SNF2-like ATPase chromatin remodeler and a core component of Nucleosome Remodeling Histone Deacetylase (NuRD) complex that regulates cell proliferation, lineage decisions, and genomic stability in a variety of cell types. In this seminar, Dr Yoshida will discuss their recent work on the role of Mi-2beta in early B cell differentiation as well as their ongoing investigation on its role on erythroid maturation.


  1. Yoshida, T. #, Hu, Y., Zhang, Z., Emmanuel, AO., Galani, K., Muhire, B., Snippert, HJ., Williams, CJ., Tolstorukov, MY., Gounari, F. and Georgopoulos, K. # (2019). Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators controls B cell differentiation. Genes Dev. Jul 1;33(13-14):763-781. doi: 10.1101/gad.321901.118. Epub 2019 May 23. PMID:31123064
  2. Joshi, I., Yoshida, T., Jena, N., Qi, X., Zhang, J., Van Etten, RA. #, and Georgopoulos, K. #. (2014) Loss of Ikaros DNA-biding function confers integrin-dependent survival of pre-B cells and progression to acute lymphoblastic leukemia.
  3. Yoshida, T., Ng, SY., Zuniga-Pflucker, JC. and Georgopoulos, K. (2006) Early hemopoietic lineage restrictions directed by Ikaros. Nat. Immunol. 7(4): 382-91. Epub 2006 Mar 5. PMID:16518393

Anyone in Kumamoto University who wants to join is welcome; however, please pre-register by the following URL to secure your seat or receive the Zoom meeting information.

Flyer (Click for a larger image):