Name: Md Naeem Hossain
           

Country:Banladesh

Lab: Laboratory of Stem Cell Stress

I am a graduate student in the Stem Cell Stress Laboratory, where I conduct research on Hematopoietic Stem Cell (HSC) biology. Below is an overview of a typical day in my life as a researcher.

I usually arrive at the university around 9 AM and start by checking emails and confirming my experiment schedule. After preparing the necessary materials, I begin my experiments at approximately 10 AM. These may include tasks such as cell culturing, plasmid extraction, lentivirus production, Western blotting, or FACS analyses. Today, I performed a Western blot to identify the flag-tagged cell surface protein. My research focuses on the gut-resident microbiota, specifically Akkermansia muciniphila (A.m.), a mucin-degrading bacterium that induces extramedullary hematopoiesis (EMH) in mice. A.m. activates HSCs, prompting them to migrate, proliferate, and differentiate into mature myeloid cells in the spleen via the TLR2 signaling pathway. Currently, I am working to identify the unknown A.m.-derived factor responsible for HSC activation.

At 12:30 PM, I typically have lunch with my lab colleagues, which provides an opportunity to learn new scientific insights from them. I make it a habit to read journal articles daily and take notes on novel findings. As a graduate student, I find the process of learning new and unique concepts both rewarding and exciting, which serves as a strong motivator and keeps my passion for science alive.

Photo1: Your research desk, research photo

Q1. Can you introduce yourself?
Hi, I'm Naeem, based in Bangladesh. I'm currently exploring Hematopoietic Stem Cell (HSC) biology at the Stem Cell Stress Laboratory.

Q2. What did you study?
My ongoing research investigates how Akkermansia muciniphila-derived factor induced extramedullary hematopoiesis (EMH) triggered by systemic stimulation and its involvement in various human diseases.

Q3. What is your most memorable experience during your time at IRCMS?
My most unforgettable moment was sharing my research findings at the Japanese Society of Hematology (JSH) conference in October, 2024.

Q4. What is your future plan? 
Upon completing my PhD, I aim to pursue a postdoctoral position to advance my research career. My goal is to establish myself as an independent researcher in academia, with a focus on stem cell biology and its role in maintaining physiological function throughout an individual's lifetime.

Q5. What do you enjoy most about your research?
What truly brings me comfort and joy about my research is the opportunity to master new techniques and explore recently published papers featuring groundbreaking concepts.

Q6. What is most fun part about studying at IRCMS?
IRCMS truly reflects the connection among international researcher and students, offering a highly supportive and diverse international atmosphere. Its unique open lab culture fosters the exchange and collaboration among different lab members, which is key to accelerating our deep understanding of research and strengthening collaboration. I thoroughly enjoyed working with individuals from different backgrounds and gaining knowledge of innovative techniques. Additionally, living in Kumamoto was a delight, as I relished exploring the local cuisine and natural wonders, such as a visit to Mt. Aso.

Photo2: Luncheon with Dr. Robert Stephenson, Senior Editor of Nature Communications, Friday, May 17^th, 2024

Q7. Any message to students
As a graduate student in Stem Cell Stress Laboratory, I would like to share that pursuing has both been challenging and incredibly rewarding. My journey involves exploring the fascinating world of Hematopoietic Stem Cell biology and the impact of microbiota on health. I encourage students to embrace every opportunity to learn new techniques, read articles and collaborate with diverse peers--experiences that have truly enriched my PhD path. Don't hesitate to ask questions, seek support, and step out of your comfort zone, whether it's in the lab or exploring new places. Stay curious, stay motivated and let's inspire each other to make a difference in science!

Photo3: Expaining the experimental scheme to Tegan (Intern student) in front of my supervisor Hitoshi Takizawa