The hybrid style symposium (on-site and online), organized by Dr. Goro Sashida of IRCMS, Kumamoto University, Japan, had been held as a part of JSPS Core-to-Core Program "Integrative approach for normal and leukemic stem cells" on January 13th and 14th, 2022. Under the theme of hematopoiesis and leukemia, seventeen speakers from respected research institutes in and out of Japan had introduced their researches.