Basic research mainly on hematopoietic stem cells in Japan will be strongly recombined with clinical research on leukemia/hematopoietic diseases to establish an international research center for the pathology of stress hematopoiesis/leukemia through integrated basic and clinical studies focusing on our theme “stress and senescence/carcinogenesis.” Simultaneously, to address the recent issues in Japan, we will educate young researchers to be more competitive with leading researchers worldwide, and enable them to launch original studies and achieve outstanding results more effectively through the research promotion system of the research center.