IRCMS International Research Center for Medical Sciences

Research

Yorifumi Satou
M.D., Ph.D.
Associate Professor

PUBLICATIONS

2016

2015

  • Shimura K, Miyazato P, Oishi S, Fujii N, Matsuoka M. Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread. Virology, 484: 364-376, 2015
  • Katsuya H, Ishitsuka K, Utsunomiya A, et al. Treatment and survival among 1594 patients with ATL. Blood,126(24):2570-7, 2015

2014

  • Zhao T, Satou Y, Matsuoka M. Development of T cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice. Arch Virol. 159: 1849-56, 2014
  • Miyazato P, Matsuoka M. Human T-cell leukemia virus type 1 and Foxp3 expression: viral strategy in vivo. Int Immunol, 8: 419-25, 2014

2013

  • Sato K, Misawa N, Iwami S, Satou Y, Matsuoka M, Ishizaka Y, Ito M, Aihara K, Dong Sung An and Koyanagi Y. HIV-1 Vpr accelerates viral replication during acute infection by exploitation of proliferating CD4+ T cells in vivo. PLoS Pathogens, 9: e1003812, 2013
  • Yamamoto-Taguchi N, Satou Y, et al.HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression. PLoS Pathogens, 9: e1003630, 2013
  • Satou Y, Matsuoka M. Virological and immunological mechanisms in the pathogenesis of human T-cell leukemia virus type 1. Rev. Medical Virology, 23: 269-80, 2013

2012

  • Satou Y, Utsunomiya A, Tanabe J, Nakagawa M, Nosaka K, Matsuoka M. HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals. Retrovirology, 9:46, 2012
  • Sugata K, Satou Y, Yasunaga J, Hara H, Ohshima K, Utsunomiya A, Mitsuyama M, and Matsuoka M. HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines, Blood, 119: 434-444, 2012
  • Satou Y, Matsuoka M. Molecular and cellular mechanism of leukemogenesis of ATL; emergent evidence of significant role of HBZ in HTLV-1-induced pathogenesis. Leukemia Research and Treatment, 2012: 213653, 2012 

2011

  • Zhao T, Satou Y, Sugata K, Miyazato P, Green PL, Imamura T, and Matsuoka M. HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator. Blood, 118: 1865-76, 2011
  • Shimizu-Kohno K, Satou Y, Arakawa F, Kiyasu J, Kimura Y, Niino D, Sugita Y, Ishikawa F, Matsuoka M, Ohshima K. Detection of human T-cell leukemia virus type 1 by means of HBZ in situ hybridization in formalin-fixed and paraffin-embedded tissues. Cancer Sci, 102: 1432-6, 2011
  • Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, and Koyanagi Y. A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice. Blood, 117:5663-73, 2011
  • Hagiya K, Yasunaga J, Satou Y, Oshima K and Matsuoka M. ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells. Retrovirology, 8:19, 2011
  • Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K, Shimizu K, Ohshima K, Green P, Ohkura N, Yamaguchi T, Ono M, Sakaguchi S, Matsuoka M, HTLV-1 bZIP Factor Induces T-cell Lymphoma and Systemic Inflammation In Vivo. PLoS Pathogens, 7: e1001274, 2011 

2010 or Before

  • Satou Y and Matsuoka M. HTLV-1 and the host immune system: How the virus disrupts immune regulation, leading to HTLV-1 associated diseases. J Clin Exp Hematopathol, 50: 1-8, 2010
  • Fan J, Ma G, Nosaka K, Tanabe J, Satou Y, Koito A, Wain-Hobson S, Vartanian JP, Matsuoka M. APOBEC3G Generates Nonsense Mutations in HTLV-1 Proviral Genomes In Vivo. Journal of Virology, 84: 7278-87, 2010
  • Saito M, Matsuzaki T, Satou Y, Yasunaga J, Saito K, Arimura K, Matsuoka M, Ohara Y. In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology. 6: 19, 2009
  • Zhao T, Yasunaga J, Satou Y, Nakao M, Takahashi M, Fujii M, Matsuoka M. Human T-cell Leukemia virus type 1 bZIP factor selectively suppresses classical pathway of NF-kB. Blood, 113: 2755-64, 2009
  • Yoshida M, Satou Y, Yasunaga JI, Fujisawa JI, Matsuoka M. Transcriptional control of spliced and unspliced HTLV-1 bZIP factor gene. Journal of Virology, 82: 9359-9368, 2008
  • Satou Y, Matsuoka M. Implication of the HTLV-I bZIP Factor Gene in the Leukemogenesis of Adult T-Cell Leukemia. International Journal of hematology, 86: 107-112, 2007
  • Satou Y, Yasunaga JI, Yoshida M, Matsuoka M. HTLV- I bZIP factor gene mRNA supports proliferation of adult T-cell leukemia cells. PNAS, 103: 720-725, 2006 
  • Doi K, Wu X, Taniguchi Y, Yasunaga JI, Satou Y, Okayama A, Nosaka K, Matsuoka M. Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states. Blood, 106: 1048-53, 2005
  • Yasunaga JI, Taniguchi Y, Nosaka K, Yoshida M, Satou Y, Sakai T, Mitsuya H, Matsuoka M. Identification of aberrantly methylated genes in association with adult T-cell leukemia. Cancer Res, 64:6002-9, 2004
  • Satou Y, Nosaka K, Koya Y, Yasunaga JI, Toyokuni S, Matsuoka M. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia, 18:1357-1363, 2004