IRCMS International Research Center for Medical Sciences


Takatsugu Ishimoto
M.D., Ph.D.
Associate Professor


  1. Selected publications

    1. Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang KK, Joyce LN, Kalpana R, Tay ST, Suzuki Y, Cho BC, Kuroda D, Arima K, Izumi D, Iwatsuki M, Baba Y, Oki E, Watanabe M, Saya H, Hirakawa K, Baba H, Tan P. Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells. Gastroenterology. 2017 In press
    2. Ishimoto T*, Baba H, Izumi D, Sugihara H, Kurashige J, Iwatsuki M, Tan P. Current perspectives towards the identification of key players in gastric cancer microRNA dysregulation. Int J Cancer. 2016 Mar 15;138(6):1337-49.
    3. Ishimoto T, Izumi D, Watanabe M, Yoshida N, Hidaka K, Miyake K, Sugihara H, Sawayama H, Imamura Y, Iwatsuki M, Iwagami S, Baba Y, Horlad H, Komohara Y, Takeya M and Baba H. * Chronic inflammation with Helicobacter pylori-infection is implicated in CD44 overexpression through miR-328 suppression in the gastric mucosa. J Gastroenterol. 2015 Jul; 50 (7):751-7.
    4. Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Okabe H, Hidaka K, Yokoyama N, Miyake K, Yoshikawa M, Nagano O, Komohara Y, Takeya M, Saya H and Baba H. * Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation. Carcinogenesis 2014 May;35(5):1003-11.
    5. Ishimoto T, Sawayama H, Sugihara H, Baba H*. Interaction between gastric cancer stem cells and the tumor microenvironment (Review). J Gastroenterol. 2014 Jul;49 (7):1111-20.
    6. Sawayama H, Ishimoto T (As co-first author), Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H. * Small molecule agonists of PPAR-γ exert therapeutic effects in esophageal cancer. Cancer Res. 2014 Jan 15; 74(2):575-85.
    7. Wada T, Ishimoto T (As co-first author), Seishima R, Tsuchihashi K, Yoshikawa M, Oshima H, Oshima M, Masuko T, Wright NA, Furuhashi S, Hirashima K, Baba H, Kitagawa Y, Saya H, Nagano O*: Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia. Cancer Sci. 2013 Oct;104(10):1323-9.
    8. Sugihara H, Ishimoto T (As co-first author), Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Komohara Y, Takeya M, Baba H. * Identification of miR-30e* regulation of Bmi1 expression mediated by tumor-associated macrophages. PLos One 2013 Nov 28;8 (11):e81839.
    9. Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T, Mogushi K, Tanaka H, Osawa T, Kanki Y, Minami T, Aburatani H, Ohmura M, Kubo A, Suematsu M, Takahashi K, Saya H and Nagano O*: Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nat. Commun. 2012 Jun 6;3:883.
    10. Ishimoto T, Nagano O*, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H: CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc- and Thereby Promotes Tumor Growth. Cancer Cell 2011 Mar 8;19(3):387-400.


Scientific awards

◆  Excellent research award of the Year of The Japanese Gastric Cancer Association, 2017
◆ Young Investigator of the Year of The Japanese Society of Gastroenterological Surgery, 2015
◆ Medical Research Encouragement Prize of The Japan Medical Association, 2011
◆ Medical Research Encouragement Prize of The Japanese Society for Gastroenterological Carcinogenesis,