IRCMS International Research Center for Medical Sciences

Research

Takamasa Ueno
Ph.D.
Associate Professor

ACHIEVEMENT

Selected publications
  1. Kuang XT, Li X, Anmole G, Mwimanzi P, Shahid A, Le AQ, Chong L, Qian H, Miura T, Markle T, Baraki B, Connick E, Daar ES, Jessen H, Kelleher AD, Little S, Markowitz M, Pereyra F, Rosenberg ES, Walker BD, Ueno T, Brumme ZL, Brockman MA. Impaired Nef function is associated with early control of HIV-1 viremia. J Virol. 2014;88(17):10200-13. Epub 2014/06/27.
  2. Kuse N, Akahoshi T, Gatanaga H, Ueno T, Oka S, Takiguchi M. Selection of TI8-8V Mutant Associated with Long-Term Control of HIV-1 by Cross-Reactive HLA-B*51:01-Restricted Cytotoxic T Cells. J Immunol. 2014;193(10):4814-22.
  3. Yanaka S, Ueno T, Shi Y, Qi J, Gao GF, Tsumoto K, Sugase K. Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex. J Biol Chem. 2014;289(35):24680-90.
  4. Motozono C, Miles JJ, Hasan Z, Gatanaga H, Meribe SC, Price DA, Oka S, Sewell AK, Ueno T. CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS One. 2013;8(6):e66152.
  5. Mwimanzi P, Markle TJ, Martin E, Ogata Y, Kuang XT, Tokunaga M, Mahiti M, Pereyra F, Miura T, Walker BD, Brumme ZL, Brockman MA, Ueno T. Attenuation of multiple Nef functions in HIV-1 elite controllers. Retrovirology. 2013;10:1.
  6. Mwimanzi P, Markle TJ, Ogata Y, Martin E, Tokunaga M, Mahiti M, Kuang XT, Walker BD, Brockman MA, Brumme ZL, Ueno T. Dynamic range of Nef functions in chronic HIV-1 infection. Virology. 2013;439(2):74-80.
  7. Hasan Z, Carlson JM, Gatanaga H, Le AQ, Brumme CJ, Oka S, Brumme ZL, Ueno T. Minor contribution of HLA class I-associated selective pressure to the variability of HIV-1 accessory protein Vpu. Biochem Biophys Res Commun. 2012;421(2):291-5.
  8. Mwimanzi P, Markle TJ, Ueno T, Brockman MA. Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants? Viruses. 2012;4(9):1711-30.
  9. Chutiwitoonchai N, Hiyoshi M, Mwimanzi P, Ueno T, Adachi A, Ode H, Sato H, Fackler OT, Okada S, Suzu S. The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement. PLoS One. 2011;6(11):e27696.
  10. Mwimanzi P, Hasan Z, Hassan R, Suzu S, Takiguchi M, Ueno T. Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages. Retrovirology. 2011;8:50.
  11. Koizumi H, Hashimoto M, Fujiwara M, Murakoshi H, Chikata T, Borghan MA, Hachiya A, Kawashima Y, Takata H, Ueno T, Oka S, Takiguchi M. Different in vivo effects of HIV-1 immunodominant epitope-specific cytotoxic T lymphocytes on selection of escape mutant viruses. J Virol. 2010;84(11):5508-19.
  12. Motozono C, Mwimanzi P, Ueno T. Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection. Protein Cell. 2010;1(6):514-9.
  13. Mwimanzi P, Hasan Z, Tokunaga M, Gatanaga H, Oka S, Ueno T. Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection. Biochem Biophys Res Commun. 2010;403(3-4):422-7.
  14. Sato Y, Takata H, Kobayashi N, Nagata S, Nakagata N, Ueno T, Takiguchi M. Failure of effector function of human CD8+ T Cells in NOD/SCID/JAK3⁻/⁻ immunodeficient mice transplanted with human CD34+ hematopoietic stem cells. PLoS One. 2010;5(10).