IRCMS International Research Center for Medical Sciences

Research

Motomi Osato
M.D., Ph.D.
Professor

ACHIEVEMENT

Selected publications

  1. Chin WLD, Watanabe-Okochi N, Wang CQ, Tergaonkar V, Osato M.
    Mouse models for Core Binding Factor leukemia
    Leukemia 29:1970-80, 2015

  2. Koh CM, Bezzi M, Low HP, Ang WX, Teo SX, Gay FP, Al-Haddawi M, Tan SY, Osato M, Sabò A, Amati B, Wee KB, Guccione E.
    MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
    Nature 523:96-100, 2015

  3. Wang QC, Krishnan V, Tay LS, Chooi JY, Chin DWL, Koh CP, Chooi JY, Nah GSK, Du L, Jacob B, Yamashita N, Tan TZ, Mori S, Taniuchi I, Tergaonkar V, Ito Y, Osato M.
    Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.
    Cell Reports 8:767-82, 2014

  4. Wang QXC, Motoda L, Satake M, Ito Y, Taniuchi I, Tergaonkar V, Osato M.
    Runx3 deficiency results in myeloproliferative disorder in aged mice.
    Blood 122:562-66, 2013

  5. Ng ELC, Yokomizo T, Yamashita N, Cirovic B, Jin H, Wen Z, Ito Y, Osato M.
    A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells.
    Stem Cells 28:1869-81, 2010

  6. Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae S.C., Komori T, Ito Y and Littman DR.
    Requirement for Runx proteins in CD4 silencing at different stages of T lymphocyte development.
    Cell 111: 621-33, 2002

  7.  Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T, Suzushima H, Takatsuki 
     K, Kanno T, Shigesada K, Ito Y. 
     Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2aB 
     associated with myeloblastic leukemias.
     Blood 93:1817-24, 1999